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POTS explained: The disorder that forced OpenAI exec Fidji Simo to take medical leave

OpenAI executive Fidji Simo is taking a temporary medical leave to treat postural tachycardia syndrome, or POTS.

The company said in an internal memo to OpenAI staffers on Friday that Simo would leave to pursue treatment and would return in several weeks.

Simo, who cofounded the Complex Disorders Alliance and the Metrodara Foundation, was diagnosed with POTS in 2019. She was initially misdiagnosed by doctors, including one who credited her health issues to being a “tired mom.”

“I was fainting constantly, I was feeling weak,” Simo told Fortune in 2021.

POTS affects the autonomic nervous system, which regulates involuntary functions such as blood pressure, heart rate, and respiration. The National Institute of Neurological Disorders and Stroke said people with POTS often have orthostatic intolerance, which is a set of symptoms that occur when a person stands up and are relieved by lying down.

“Symptoms of orthostatic intolerance, which often include dizziness or fainting, happen because not enough blood flows back to the heart when the person moves from a lying down or seated position to standing up,” the agency said.

Through her organizations, scientists are conducting research and trying to find cures for disorders like POTS.

Who is most likely to get POTS?

Although anyone can be diagnosed with POTS, the disorder mostly affects people between 15 and 50 years old. POTS is more common in women than in men.

“POTS commonly begins after a pregnancy, major surgery, puberty, trauma, or a viral illness. Some people report an increase in episodes of POTS right before their menstrual periods,” the National Institute of Health said.

People with a family history of POTS are at a “higher risk.”

What are the symptoms of POTS?

A “classic” symptom of POTS is a fast heartbeat, but the disorder can also cause dizziness, lightheadedness, fainting, and heart palpitations that occur when standing up.

“Some people may have blurred vision or tunnel vision, weakness in the legs, chest pain or other pain, fatigue, sleep problems, digestive issues, shortness of breath, and difficulty concentrating,” the agency said.

Over time, POTS symptoms can improve, but some may remain or persist for a long time.

Why is POTS hard to diagnose?

The agency said scientists aren’t sure what exactly causes POTS.

“Doctors typically begin by reviewing a person’s medical history and discussing their symptoms,” the agency says. “They may also measure heart rate and blood pressure and observe how the body responds to changes in position, such as standing up quickly.”

How is POTS treated?

Treatment for POTS is focused on managing issues with blood flow and low blood volume.

Some medications can offer short-term relief, but scientists are still determining their long-term effectiveness. Lifestyle changes can help lessen symptoms, including increasing salt intake and staying hydrated.

How does COVID-19 impact POTS?

Some people with long-term COVID have developed POTS, but scientists are still determining why, according to the agency.

People with POTS symptoms related to COVID-19 can also experience anxiety, depression, cognitive issues, brain fog, and sleep problems.




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A map shows a flight path from Dubai to Thessaoliniki, then onto Nuremberg and finally to Stuttgart, with Iran also labelled.

Airlines are being forced into huge, hourslong diversions to avoid flying over Iran — with some planes even needing to refuel

Some European airlines are facing significant delays as their flights from the Middle East make fuel stops after being rerouted around Iran.

Sunday’s Eurowings Flight 1153, from Dubai, made two stopovers on its way to Stuttgart, Germany.

It first flew for just over 6 hours to Thessaloniki, Greece, for a refuelling stop, data from Flightradar24 shows.

After about 50 minutes on the ground, it took off again for Germany. However, the 2-hour flight landed in Nuremberg around 1:30 a.m.

It appears that it was too late to land in Stuttgart due to nighttime flight restrictions.

Therefore, it wasn’t until the next morning that the plane made another 30-minute flight to reach its intended destination.

In all, it arrived in Stuttgart 11 hours after the usual direct flight from Dubai.

A Eurowings spokesperson told Business Insider that its owner, the Lufthansa Group, decided not to fly over Iranian or Iraqi airspace as a precautionary measure.

They added that the refueling stop was “due to a longer flight distance and stronger headwinds on the alternative route at the time.”

“In the event of such refueling, we inform our passengers accordingly before departure in Dubai,” they said.

It isn’t the only European airline that has made such adjustments.

A spokesperson for Wizz Air, another budget airline, told Reuters that some of its flights from Dubai and Abu Dhabi would make “refuelling and crew change” stops in Cyprus or Thessaloniki.

Budget airlines are perhaps more susceptible to refueling stops because they typically operate only one type of airplane.

Their single-aisle jets are already near their maximum range for flights between the Middle East and Europe.

Meanwhile, the likes of British Airways and Air France are flying to Dubai with Boeing 777 or 787 jets. These twin-aisle airplanes have much larger fuel tanks, so any rerouting won’t require a fuel stop.

Over the past few days, flight-tracking data shows British Airways’ flight from Dubai to London has flown over Saudi Arabia instead of Iraq — taking around an hour longer than usual.

Earlier this month, the European Union Aviation Safety Agency warned airlines not to fly over Iran.

“The presence and potential use of weapons and air defense systems create a high risk for civilian flights,” it said in a statement, per Reuters. “There is a high probability of misidentification, against the backdrop of a possible American attack as well as the high alert status of Iran’s air defense systems.”




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